Title:Oxidation of NADH and ROS production by respiratory complex I.
Authors:Vinogradov AD; Grivennikova VG
Publication:Biochim Biophys Acta. 2016 Jul;1857(7):863-71. doi: 10.1016/j.bbabio.2015.11.004. Epub 2015 Nov 10.
Kinetic characteristics of the proton-pumping NADH:quinone reductases (respiratory complexes I) are reviewed. Unsolved problems of the redox-linked proton translocation activities are outlined. The parameters of complex I-mediated superoxide/hydrogen peroxide generation are summarized, and the physiological significance of mitochondrial ROS production is discussed. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt.