Title:Effect of homocysteine on properties of neutrophils activated in vivo.
Authors:Bryushkova EA; Vladychenskaya EA; Stepanova MS; Boldyrev AA
Publication:Biochemistry (Mosc). 2011 Apr;76(4):467-72.
We have found that neutrophils begin to express NMDA receptors on their membranes after in vivo activation. These receptors are the target for action of homocysteine (HC). After incubation of activated neutrophils with HC, the degranulation process is stimulated and generation of reactive oxygen species is increased. We conclude that expression of NMDA receptors on neutrophil membrane makes neutrophils sensitive to HC. Thus, hyperhomocysteinemia may induce additional stimulation of immune competent cells.