Article

Title:Cardioprotective effect of histidine-containing dipeptides in pharmacological cold cardioplegia.
Authors:Bokeriya LA; Boldyrev AA; Movsesyan RR; Alikhanov SA; Arzumanyan ES; Nisnevich ED; Artyukhina TV; Serov RA
Publication:Bull Exp Biol Med. 2008 Mar;145(3):323-7.
PubmedID19039934
Abstract
The cardioprotective effect of cardioplegic solution based on histidine-containing dipeptides was evaluated on isolated rat heart under conditions of hyporthermia and long ischemia. The use of natural dipeptides in cardioplegic solutions promoted an increase in the buffer capacity of myocardial cells and creation of an additional anti-ischemic effect under conditions of long ischemia and hypothermia.